Factor·arcadia
Compound 48/80 treatment
Exposure to compound 48/80, a polymer MRGPRX2 agonist and standard mast cell activator, used at typical degranulation assay concentrations.
Confidence
90%
active
Source
Audrey Bell et al. (2025). Can compound 48/80 be used for safe mast cell degranulation assays? doi:10.57844/arcadia-3207-4695 ↗
Connections (7)
Compound 48/80 is toxic to HMC1.2 and RBL-2H3 cellsAssociation
48/80 induces β-hexosaminidase release in mast cell modelsAssociation
No non-toxic activity window for 48/80 in HMC1.2 and RBL-2H3Association
β-hex release by 48/80 is an artifact of membrane permeabilizationAssociation
Mechanism of 48/80 toxicity is unrelated to MRGPRX2Association
48/80 may cause non-specific membrane permeabilizationAssociation
48/80 toxicity observed only in HMC1.2 and RBL-2H3Association