Association·arcadia
β-hex release by 48/80 is an artifact of membrane permeabilization
Claim that β-hexosaminidase release observed with 48/80 treatment is due to membrane permeabilization (cell death), not genuine degranulation.
Confidence
90%
active
Evidence Quote
“β-hex released by 48/80 is an artifact of membrane permeabilization and not the result of a biological process induced by this compound.”
Relationship
β-hexosaminidase release artifact of toxicity hmc1.2 rbl2h3
Connections (6)
Compound 48/80 treatmentFactor
HMC1.2 cell line (human mast cell model)Factor
RBL-2H3 cell line (rat basophil/mast cell model)Factor
Failure to find a non-toxic activity window for 48/80 in mast cell modelsInferenceChain
48/80 induces β-hexosaminidase release in mast cell modelsAssociation
Limits of using compound 48/80 and standard mast cell lines in tick saliva researchInferenceChain