Factor·arcadia
β-hexosaminidase release
Release of β-hexosaminidase (marker of degranulation) from mast cell or basophil lines into the extracellular supernatant.
Confidence
90%
active
Source
Audrey Bell et al. (2025). Can compound 48/80 be used for safe mast cell degranulation assays? doi:10.57844/arcadia-3207-4695 ↗
Connections (5)
48/80 induces β-hexosaminidase release in mast cell modelsAssociation
No non-toxic activity window for 48/80 in HMC1.2 and RBL-2H3Association
β-hex release by 48/80 is an artifact of membrane permeabilizationAssociation
HMC1.2 cells are poorly granulatedAssociation
Other non-toxic inducers of degranulation may existAssociation