Association·arcadia
48/80 induces β-hexosaminidase release in mast cell models
Claim that only compound 48/80, among tested mast cell activators, induces β-hexosaminidase release (degranulation) in both HMC1.2 and RBL-2H3 cell lines.
Confidence
100%
active
Evidence Quote
“Only 48/80 induced β-hexosaminidase release from either HMC1.2 or RBL-2H3”
Relationship
Compound 48/80 treatment increases β-hexosaminidase release
Connections (4)
Assay inactivation due to toxicity and lack of suitable activatorInferenceChain
48/80 induces β-hexosaminidase release in mast cell modelsAssociation
Limits of using compound 48/80 and standard mast cell lines in tick saliva researchInferenceChain
Divergent activator mechanisms via MRGPRX2 pathwayInferenceChain
Evidence
“Reference to Karagiannis SN et al. (2013). Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment.”
Karagiannis SN et al. (2013). Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment doi:10.1128/microbiolspec.aid-0006-2012 ↗
“Reference to Yang T-LB, Kim BS. (2019). Pruritus in allergy and immunology.”