Association·arcadia
No non-toxic activity window for 48/80 in HMC1.2 and RBL-2H3
Claim that there is no concentration of compound 48/80 that induces degranulation without causing toxicity in HMC1.2 and RBL-2H3 cell lines.
Confidence
90%
active
Evidence Quote
“We found no concentration of 48/80 that we could use to induce degranulation without causing toxicity.”
Connections (7)
Toxicity in HMC1.2 and RBL-2H3 cellsFactor
HMC1.2 cell line (human mast cell model)Factor
RBL-2H3 cell line (rat basophil/mast cell model)Factor
Failure to find a non-toxic activity window for 48/80 in mast cell modelsInferenceChain
48/80 induces β-hexosaminidase release in mast cell modelsAssociation
Limits of using compound 48/80 and standard mast cell lines in tick saliva researchInferenceChain
Divergent activator mechanisms via MRGPRX2 pathwayInferenceChain