Factor·arcadia
RBL-2H3 cell line (rat basophil/mast cell model)
RBL-2H3 is a rat leukemia cell line with basophil and mast cell characteristics, widely used for in vitro mast cell activation and degranulation assays.
Confidence
80%
active
Source
Audrey Bell et al. (2025). Can compound 48/80 be used for safe mast cell degranulation assays? doi:10.57844/arcadia-3207-4695 ↗
Connections (5)
No non-toxic activity window for 48/80 in HMC1.2 and RBL-2H3Association
β-hex release by 48/80 is an artifact of membrane permeabilizationAssociation
48/80 toxicity observed only in HMC1.2 and RBL-2H3Association
Other non-toxic inducers of degranulation may existAssociation
48/80 may cause non-specific membrane permeabilizationAssociation