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Association·arcadia

48/80 may cause non-specific membrane permeabilization

Claim that 48/80 likely causes non-specific membrane permeabilization, possibly due to its amphipathic chemical structure.

Confidence
70%
active

Evidence Quote

“48/80 may non-specifically permeabilize the membrane.”

Relationship

Compound 48/80 treatment may cause Membrane permeabilization

Arguments

Compound 48/80 treatmentsubject
Membrane permeabilizationobject

Connections (3)

HMC1.2 cell line (human mast cell model)Factor
RBL-2H3 cell line (rat basophil/mast cell model)Factor
48/80 induces β-hexosaminidase release in mast cell modelsAssociation

Evidence

“Reference to Basic local alignment search tool”

Altschul SF et al. (1990). Basic local alignment search tool doi:10.1016/s0022-2836(05)80360-2 ↗

“Reference to QGB: Combined Use of Sequence Similarity and Codon Bias”

STATES DJ & GISH W (1994). QGB: Combined Use of Sequence Similarity and Codon Bias for Coding Region Identification doi:10.1089/cmb.1994.1.39 ↗

“Reference to AlphaFold Protein Structure Database”

Varadi M et al. (2021). AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models doi:10.1093/nar/gkab1061 ↗

“Reference to AlphaFold protein structure prediction”

Jumper J et al. (2021). Highly accurate protein structure prediction with AlphaFold doi:10.1038/s41586-021-03819-2 ↗