Association·arcadia
Mechanism of 48/80 toxicity is unrelated to MRGPRX2
Claim that 48/80’s toxicity is not caused by its canonical MRGPRX2 agonist activity but by some other, as-yet-unknown mechanism.
Confidence
80%
active
Evidence Quote
“48/80 toxicity is not the direct result of MRGPRX2 activation but rather of some other as-yet-undescribed effect.”
Relationship
toxicity hmc1.2 rbl2h3 not due to MRGPRX2 receptor
Evidence
“Reference to the study examining genistein's inhibition of MRGPRX2 in relation to 48/80-induced anaphylactoid shock.”
(2020). Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2). doi:10.3390/molecules25051028 ↗