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Transcription factor coordination mediates gene network shifts in microgravity — NASA Knowledge Graph

InferenceChain·nasa

Transcription factor coordination mediates gene network shifts in microgravity

Reasoning path connecting how key transcription factors such as HY5, TCP, and ARF coordinate differentially regulated gene clusters, explaining observed up- and down-regulation of auxin signaling, vesicle transport, and stress/defense genes in microgravity.

Confidence

80%

◑partialactivecomplexity: low

Reasoning Steps (2)

HY5 acts as integrator of light and environmental signalsStep 1

TCP and ARF transcription factors co-regulate auxin-responsive gene clustersStep 2

Source

Synthesis for current paper

Connections (4)

Microgravity upregulates auxin signaling genesAssociation

Microgravity upregulates vesicle-mediated transport genesAssociation

Microgravity downregulates stress response genesAssociation

Microgravity enriches HY5 target gene regulationAssociation