Microgravity upregulates vesicle-mediated transport genes

Association·nasa

Genes involved in vesicle-mediated transport, including coat protein complex, Sec23/24, Golgi and endomembrane-related proteins, are upregulated under microgravity in Arabidopsis shoots.

Confidence

80%

active

Evidence Quote

“Genes involved in vesicle-mediated transport were upregulated in microgravity.”

Relationship

microgravity increases Vesicle-mediated transport genes

Arguments

Vesicle-mediated transport genesobject

Connections (12)

Microgravity alters plant transcriptional networks via coordinated gene set regulationInferenceChain

Spaceflight alters plant gene expressionAssociation

Microgravity triggers coordinated transcriptional shifts impacting auxin signaling, vesicle transport, and stress response in leavesInferenceChain

Spaceflight co-regulates cell wall remodeling and developmental gene responsesInferenceChain

Vesicle-mediated transport gene regulation in microgravityInferenceChain

Transcription factor coordination mediates gene network shifts in microgravityInferenceChain

Gene set analysis and annotation tools enable transcriptional network interpretation in spaceflight plant studiesInferenceChain

Microgravity and space environment coordinate organelle stress and gene expression shiftsInferenceChain

Mechanisms underlying microgravity-induced gene regulationInferenceChain

Organ- and layer-specific regulation of gene expression under spaceflightInferenceChain

Fractional gravity orchestrates root transcriptional adaptationInferenceChain

Integration of TCP11, miR156/SPL, and HY5 in plant developmental regulationInferenceChain

Evidence

“ESA overview of experimental opportunities on the International Space Station for plant biology”

(1999). Spaceﬂight opportunities on the ISS for plant research–the ESA perspective doi:10.1016/s0273-1177(99)00413-5 ↗

“Tool for discovering position-sensitive sequence motifs in genomic data.”

Davis, I. W. et al. (2012). POWRS: position-sensitive motif discovery. doi:10.1371/journal.pone.0040373 ↗

“Spaceflight experiment identifying specific changes in Arabidopsis protein profiles.”

(2014). Spaceﬂight induces speciﬁc alterations in the proteomes of arabidopsis doi:10.1089/ast.2014.1210 ↗

“Review of bioregenerative life support system requirements for long-term space missions to the moon or Mars.”

(2016). How to establish a bioregenerative life support system for long-term crewed missions to the moon or mars doi:10.1089/ast.2016.1477 ↗

“Inline reference to Hwang, I., and Robinson, D. G. (2009) on transport vesicle formation in plant cells.”

Hwang, I. & Robinson, D.G. (2009). Transport vesicle formation in plant cells doi:10.1016/j.pbi.2009.09.012 ↗

“Study using glycome profiling and immunohistochemistry to uncover cell wall changes in Arabidopsis roots during spaceflight.”

(2023). Glycome profiling and immunohistochemistry uncover changes in cell walls of Arabidopsis thaliana roots during spaceflight doi:10.1038/s41526-023-00312-0 ↗

“Meta-analysis paper on proteomic responses of Arabidopsis seedlings to the spaceflight environment and sources of variability”

Functional meta-analysis of the proteomic responses of Arabidopsis seedlings to the spaceflight environment reveals multi-dimensional sources of variability across spaceflight experiments doi:10.3390/ijms241914425 ↗