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Association·nasa

Microgravity enriches HY5 target gene regulation

Genes differentially expressed in microgravity are significantly enriched for HY5 transcription factor targets, affecting both upregulated (developmental, auxin transport) and downregulated (abiotic/biotic stress) gene sets.

Confidence
80%
active

Evidence Quote

“Genes differentially expressed in microgravity are significantly enriched for HY5 target genes.”

Relationship

microgravity enriches HY5 target genes

Arguments

HY5 target genesobject

Connections (6)

Spaceflight alters plant gene expressionAssociation
Transcription factor control coordinates SAUR gene expression and adaptive growthInferenceChain
Transcription factor coordination mediates gene network shifts in microgravityInferenceChain
Epigenomic regulation coordinates organ-specific gene expression in spaceflightInferenceChain
Mechanisms underlying microgravity-induced gene regulationInferenceChain
Integration of TCP11, miR156/SPL, and HY5 in plant developmental regulationInferenceChain

Evidence

“Review on HY5 transcription factor’s various roles in plant growth and development.”

(2016). The multifaceted roles of HY5 in plant growth and development doi:10.1016/j.molp.2016.07.002 ↗

“RNAseq study examining how Arabidopsis responds to partial gravity and blue light stimulation during spaceflight.”

(2019). RNAseq analysis of the response of Arabidopsis thaliana to fractional gravity under blue-light stimulation during spaceflight doi:10.3389/fpls.2019.01529 ↗

“Study mapping HY5 binding sites and roles in Arabidopsis development.”

Lee, J. et al. (2007). Analysis of transcription factor HY5 genomic binding sites revealed its hierarchical role in light regulation of development doi:10.1105/tpc.106.047688 ↗

“Study identifying how spaceflight causes organ-specific changes in the Arabidopsis transcriptome”

(2013). Organ-specific remodeling of the Arabidopsis transcriptome in response to spaceflight doi:10.1186/1471-2229-13-112 ↗

“Study dissecting the transcriptome response in Arabidopsis during spaceflight and its relevance for physiological adaptation”

(2017). Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight? doi:10.1371/journal.pone.0180186 ↗

“Study on the roles of elongator complex subunit 2 and methyltransferase 1 in modulating Arabidopsis spaceflight responses”

(2021). Epigenomic regulators elongator complex subunit 2 and methyltransferase 1 differentially condition the spaceflight response in Arabidopsis doi:10.3389/fpls.2021.691790 ↗

“Study describing hierarchical transcription factor network mediating plant environmental stress responses.”

Song, L. et al. (2016). A transcription factor hierarchy defines an environmental stress response network doi:10.1126/science.aag1550 ↗

“Review of microRNAs and their function in regulating plant interactions with the environment.”

Song, X. et al. (2019). MicroRNAs and their regulatory roles in plant–environment interactions doi:10.1146/annurev-arplant-050718-100334 ↗

“Review of molecular responses and signaling pathway cross-talk in plant dehydration and low temperature stress.”

Shinozaki, K. & Yamaguchi-Shinozaki, K. (2000). Molecular responses to dehydration and low temperature: differences and cross-talk between two stress signaling pathways doi:10.1016/S1369-5266(00)80068-0 ↗

“Review of APETALA2/Ethylene Responsive Factors (AP2/ERFs) in plants and their relevance to crop improvement.”

Srivastava, R. & Kumar, R. (2019). The expanding roles of APETALA2/Ethylene Responsive Factors and their potential applications in crop improvement doi:10.1093/bfgp/elz001 ↗