Association·arcadia
Uncertainty in confidence of predicted targets for OG0000058 family
There is uncertainty about how much confidence to have in computational predictions of OG0000058 family tick protease inhibitors targeting human proteases, due to presence of physiologically irrelevant and plausible targets and lack of experimental benchmarking data.
Confidence
85%
active
Evidence Quote
“We have no idea how much confidence we should have in these hits; some targets seem reasonable, others are physiologically irrelevant; no benchmarking data available”
Relationship
Tick protease inhibitor family OG0000058 uncertain confidence human proteases
Arguments
Connections (8)
Reasoning on limitations in confidence of tick protease inhibitor target predictionsInferenceChain
Animal models are poor predictors of human toxicitiesAssociation
Reasoning on tick protease inhibitor host target predictions and confidenceInferenceChain
Reasoning on tick protease inhibitor target predictions and confidenceInferenceChain
Reasoning on protein structure prediction and interaction confidenceInferenceChain
Role of Cathepsin G and SERPINA3 variants in psoriasis inflammationInferenceChain
Kallikrein-mediated skin barrier dysfunction and inflammation pathwayInferenceChain
Reasoning on tick protease inhibitor target predictions and evolutionary evidenceInferenceChain