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Reasoning on tick protease inhibitor target predictions and evolutionary evidence — ARCADIA Knowledge Graph

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Reasoning on tick protease inhibitor target predictions and evolutionary evidence

Integrates computational target prediction confidence with evolutionary patterns and functional characterization to reason about the host protease targeting by tick protease inhibitors.

Confidence

80%

◑partialactivecomplexity: mid

Reasoning Steps (3)

Tick protease inhibitor target diversity and plausibilityStep 1

Non-parallel evolution supports functional specificityStep 2

Functional characterization confirms serpin family activityStep 3

Source

Synthesis for current paper

Connections (3)

Tick protease inhibitors target human serine proteasesAssociation

OG0000058 family members target human serine proteasesAssociation

Uncertainty in confidence of predicted targets for OG0000058 familyAssociation