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OG0000058 family members target human serine proteases

AF-Multimer predicts that multiple members of the tick protease inhibitor family OG0000058 have high-confidence interactions with human serine proteases, including targets expressed by skin and immune cells as well as pancreatic enzymes.

Confidence
90%
active

Evidence Quote

“Other members of the OG0000058 family also had high-confidence interactions predicted for the 34 proteases from the initial search”

Relationship

Tick protease inhibitor family OG0000058 interacts Human serine proteases expressed in skin and immune cells

Arguments

Tick protease inhibitor family OG0000058subject
Human serine proteases expressed in skin and immune cellsobject

Connections (8)

Reasoning on limitations in confidence of tick protease inhibitor target predictionsInferenceChain
IL-23R/IL-22 circuit regulates epithelial Serum amyloid AAssociation
Reasoning on tick protease inhibitor host target predictions and confidenceInferenceChain
Reasoning on tick protease inhibitor target predictions and confidenceInferenceChain
Reasoning on protein structure prediction and interaction confidenceInferenceChain
Role of Cathepsin G and SERPINA3 variants in psoriasis inflammationInferenceChain
Kallikrein enzyme expression impacts epidermal barrier and skin pathologyInferenceChain
Reasoning on tick protease inhibitor target predictions and evolutionary evidenceInferenceChain

Evidence

“Evidence showing AF-Multimer prediction results for 10 members of the tick OG0000058 protease inhibitor family targeting 34 human serine proteases, scored by pDockQ and AF-Multimer confidence metrics.”

Confidence in computational predictions of tick protease inhibitor targets

“Reference describing AlphaFold-Multimer structural PPI predictions applied to multiple members of OG0000058 tick protease inhibitor family.”

Confidence in computational predictions of tick protease inhibitor targets

“Discusses instances of parallel and non-parallel evolutionary patterns relevant to gene family diversification and targeting of host proteins.”

(Non)Parallel Evolution

“Evidence supporting that rare loss-of-function mutations in SERPINA3 are associated with generalized pustular psoriasis, altering inhibition of cathepsin G.”

Evidence for SERPINA3 loss-of-function mutation in pustular psoriasis

“Evidence discussing parallel and non-parallel evolutionary patterns relevant to gene family diversification and host protein targeting.”