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Role of Cathepsin G and SERPINA3 variants in psoriasis inflammation — ARCADIA Knowledge Graph

InferenceChain·arcadia

Role of Cathepsin G and SERPINA3 variants in psoriasis inflammation

This chain explains how SERPINA3 variants impair inhibition of cathepsin G, leading to activation of IL-36γ and promotion of psoriasis inflammation, supported by loss-of-function evidence and therapeutic targeting rationale.

Confidence

90%

◑provedactivecomplexity: mid

Reasoning Steps (3)

SERPINA3 loss-of-function variants reduce cathepsin G inhibitionStep 1

Cathepsin G cleaves and activates IL-36γStep 2

Targeting neutrophil proteases as therapeutic strategyStep 3

Source

Synthesis for current paper

Connections (3)

Tick protease inhibitors target human serine proteasesAssociation

OG0000058 family members target human serine proteasesAssociation

Uncertainty in confidence of predicted targets for OG0000058 familyAssociation