InferenceChain·arcadia

Role of Cathepsin G and SERPINA3 variants in psoriasis inflammation

This chain explains how SERPINA3 variants impair inhibition of cathepsin G, leading to activation of IL-36γ and promotion of psoriasis inflammation, supported by loss-of-function evidence and therapeutic targeting rationale.

Confidence
90%
◑provedactivecomplexity: mid

Reasoning Steps (3)

SERPINA3 loss-of-function variants reduce cathepsin G inhibitionStep 1
Cathepsin G cleaves and activates IL-36γStep 2
Targeting neutrophil proteases as therapeutic strategyStep 3

Source

Synthesis for current paper

Connections (3)

Tick protease inhibitors target human serine proteasesAssociation
OG0000058 family members target human serine proteasesAssociation
Uncertainty in confidence of predicted targets for OG0000058 familyAssociation