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Tick protease inhibitors target human serine proteases

AF-Multimer predicts interactions between a tick protease inhibitor and multiple human serine proteases expressed in skin and immune cells, indicating potential host protease target inhibition.

Confidence
90%
active

Evidence Quote

“AF-Multimer predicts 34 targets for a single representative of OG0000058 tick protease inhibitors, many expressed in skin or immune cells.”

Relationship

Tick protease inhibitor family OG0000058 interacts with Human serine proteases expressed in skin and immune cells

Arguments

Tick protease inhibitor family OG0000058subject
Human serine proteases expressed in skin and immune cellsobject

Connections (10)

Reasoning on tick protease inhibitor target predictions and confidence metricsInferenceChain
IL-23R/IL-22 circuit regulates epithelial Serum amyloid AAssociation
Reasoning on tick protease inhibitor host target predictions and confidenceInferenceChain
Reasoning on tick protease inhibitor target predictions and confidenceInferenceChain
Reasoning on protein structure prediction and interaction confidenceInferenceChain
Role of Cathepsin G and SERPINA3 variants in psoriasis inflammationInferenceChain
Neutrophil elastaseFactor
Mast cells in type 2 skin inflammationFactor
Mast cell chymaseFactor
Reasoning on tick protease inhibitor target predictions and evolutionary evidenceInferenceChain

Evidence

“Evidence from AF-Multimer structural PPI prediction identifying 34 human serine proteases as likely targets of tick protease inhibitor OG0000058 with confidence scores above 0.75.”

ProteinCartography-based target prediction of tick protease inhibitors

“Comparative analysis using pDockQ scores showed only four of 34 AF-Multimer predicted targets fell below the threshold of 0.5; pDockQ provided better biological plausibility for top hits.”

ProteinCartography-based target prediction of tick protease inhibitors

“Discusses instances of parallel and non-parallel evolutionary patterns relevant to gene family diversification and targeting of host proteins.”

(Non)Parallel Evolution

“Evidence supporting that rare loss-of-function mutations in SERPINA3 are associated with generalized pustular psoriasis, altering inhibition of cathepsin G.”

Evidence for SERPINA3 loss-of-function mutation in pustular psoriasis

“Evidence discussing parallel and non-parallel evolutionary patterns relevant to gene family diversification and host protein targeting.”