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Animal models are poor predictors of human toxicities

Claim that pre-clinical animal models used in research do not reliably predict toxic responses in humans during phase 1 oncology trials.

Confidence
90%
active

Evidence Quote

“Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials.”

Relationship

Pre-clinical animal models fails to predict Prediction of human toxicities

Arguments

Pre-clinical animal modelssubject
Prediction of human toxicitiesobject

Connections (3)

Limits of animal models and need for diverse research organismsInferenceChain
Animal models are poor predictors of human toxicitiesAssociation
Reasoning on mouse versus human immunology relevanceInferenceChain

Evidence

“Reference highlighting limitations of animal models for predicting human toxicity”

Atkins JT et al. (2020). Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials doi:10.1038/s41416-020-01033-x ↗

“Reference discussing the differences between mouse and human immunology.”

(2004). Of Mice and Not Men: Differences between Mouse and Human Immunology doi:10.4049/jimmunol.172.5.2731 ↗