InferenceChain·arcadia

Kallikrein-mediated skin barrier dysfunction and inflammation pathway

This chain explains the role of multiple kallikrein enzymes in disrupting epidermal barrier function and promoting skin inflammation and pruritus, supported by genetic, experimental, and clinical evidence.

Confidence
90%
◑provedactivecomplexity: mid

Reasoning Steps (3)

KLK5 and KLK7 dual inhibition ameliorates Netherton syndrome and atopic dermatitisStep 1
KLK7 promotes itch in atopic dermatitis independently of skin inflammationStep 2
Kallikrein-related peptidases are promising targets for skin desquamation diseasesStep 3

Source

Synthesis for current paper

Connections (1)

Uncertainty in confidence of predicted targets for OG0000058 familyAssociation