Factor·arcadia
TM-score (structural similarity)
Score indicating structural similarity between two protein structures, ranging from 0 (different) to 1 (identical), used in ProteinCartography analyses.
Confidence
100%
active
Source
ProteinCartography Main Paper
Connections (25)
Proteins within the same cluster have similar biochemical functionsAssociation
Proteins in different clusters have functional differencesAssociation
TM-score assesses protein structure template qualityAssociation
Subset of protein families show structural conservation despite sequence and phylogenetic diversityAssociation
Some protein families exhibit near-perfect structural conservation despite significant sequence divergenceAssociation
Binning of TM-score to define structural profilesAssociation
Assignment of high mean TM-score to rigidityAssociation
Assignment of high TM-score standard deviation to plasticityAssociation
Difference in median TM-score between structural profilesAssociation
Sequence features correlate with structural profilesAssociation
Structure-based protein comparison enables mapping of protein relationshipsAssociation
Metadata overlay enables detailed protein analysisAssociation
Structure classification resources enable protein structure mappingAssociation
Protein databases facilitate knowledge integrationAssociation
Protein Data Bank is phylogenetically biasedAssociation
Species abundance bias in PDBAssociation
UniProt, InterPro, and Pfam enable protein annotationAssociation
TM-align enables protein structure alignmentAssociation
Sequence similarity networks visualize relationshipsAssociation
Functional annotation prediction for protein sequencesAssociation
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High mean TM-score indicates cluster similarityAssociation
High TM-score indicates cluster compactnessAssociation
Confidence in computational predictions of tick protease inhibitor targetsResearchQuestion