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UniProt, InterPro, and Pfam enable protein annotation

Claim that UniProtKB/Swiss-Prot, InterPro, and Pfam databases enable or support detailed protein annotation and classification.

Confidence
80%
active

Evidence Quote

“UniProtKB/Swiss-Prot, InterPro, and Pfam enable annotation of proteins”

Relationship

UniProtKB SwissProt enables Pfam database

Arguments

TM-score (structural similarity)subject
Number of Pfam domainsobject

Connections (2)

Reasoning on protein annotation and classification resourcesInferenceChain
Ras GTPase subfamilies cluster togetherAssociation

Evidence

“Reference describing expert curation and scalability in the UniProtKB/Swiss-Prot protein knowledgebase.”

Author(s) unavailable (2017). On expert curation and scalability: UniProtKB/Swiss-Prot as a case study doi:10.1093/bioinformatics/btx439 ↗

“Reference describing the InterPro protein families and domains database.”

Blum M et al. (2020). The InterPro protein families and domains database: 20 years on doi:10.1093/nar/gkaa977 ↗

“Reference for the Pfam protein families database.”

Mistry J et al. (2020). Pfam: The protein families database in 2021 doi:10.1093/nar/gkaa913 ↗

“Evidence describing a community perspective and roadmap for the functional annotation of protein families.”

de Crécy-lagard V et al. (2022). A roadmap for the functional annotation of protein families: a community perspective doi:10.1093/database/baac062 ↗