Factor·arcadia
Structural conservation
Similarity in three-dimensional structure between candidate proteins and known actins, often assessed using computational models and structure comparison tools like AlphaFold and Foldseek.
Confidence
90%
active
Source
Prachee Avasthi et al. (2022). Defining actin: Combining sequence, structure, and functional analysis to propose useful boundaries doi:10.57844/arcadia-ynth-kh70 ↗
Connections (7)
Pipeline combines sequence, structure, and functionAssociation
Structural similarity often diverges from sequence similarityAssociation
Structural analysis finds actin fold elements in non-actin proteinsAssociation
Low correlation between structural and sequence conservationAssociation
Importance of considering multiple conservation criteriaAssociation
Polymerizability correlates with structural conservationAssociation
Conservation of polymerization contacts distinguishes actin typesAssociation