Association·arcadia

Structural analysis finds actin fold elements in non-actin proteins

Large-scale structural analysis reveals aspects of the actin fold are conserved in proteins such as sugar kinases and heat shock proteins.

Confidence
70%
active

Evidence Quote

“Large-scale analysis could reveal which aspects of the actin fold are conserved in sugar kinases and heat shock proteins”

Relationship

Sugar kinases and heat shock proteins conserved elements Structural conservation

Arguments

Sugar kinases and heat shock proteinssubject
Structural conservationobject

Connections (3)

Structural similarity often diverges from sequence similarityAssociation
Reasoning about sequence vs structural conservation in actinsInferenceChain
Reasoning: Evolutionary conservation and divergence of actin structure and functionInferenceChain

Evidence

“Reference on ATPase domain common to several protein families”

Bork P et al. (1992). An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins doi:10.1073/pnas.89.16.7290 ↗