Association·arcadia
Structural similarity often diverges from sequence similarity
Claim that structural conservation and sequence conservation do not strongly correlate across actins; high sequence similarity can coexist with structural divergence.
Confidence
90%
active
Evidence Quote
“Structural conservation does not show strong correlation with sequence conservation; high sequence similarity can be accompanied by large structural divergence.”
Relationship
Global percent sequence identity diverges foldseek evalue
Connections (3)
Evidence
“Structural conservation does not show strong correlation with sequence conservation; evidence from large-scale analysis (Fig 3F) shows high sequence similarity can coexist with structural divergence.”
Structural and functional distinctions of actins