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Structural similarity often diverges from sequence similarity — ARCADIA Knowledge Graph

Association·arcadia

Structural similarity often diverges from sequence similarity

Claim that structural conservation and sequence conservation do not strongly correlate across actins; high sequence similarity can coexist with structural divergence.

Confidence
90%
active

Evidence Quote

“Structural conservation does not show strong correlation with sequence conservation; high sequence similarity can be accompanied by large structural divergence.”

Relationship

Global percent sequence identity diverges foldseek evalue

Arguments

Global percent sequence identitysubject
Structural conservationobject

Connections (3)

Reasoning on divergence and interplay of sequence and structure conservation in actinsInferenceChain
Structural similarity often diverges from sequence similarityAssociation
Reasoning about sequence vs structural conservation in actinsInferenceChain

Evidence

“Structural conservation does not show strong correlation with sequence conservation; evidence from large-scale analysis (Fig 3F) shows high sequence similarity can coexist with structural divergence.”

Structural and functional distinctions of actins