Viruses use mimicry to modulate host immunity
Claim that viruses, especially large dsDNA viruses, use protein mimicry to alter or modulate the host immune response.
Evidence Quote
“Viruses use protein mimicry to modulate host immunity.”
Relationship
Connections (10)
Evidence
“Reference: Alcami A. (2003), describing viral mimicry of immune signaling molecules.”
“Reference on molecular mimicry enabling viral immune evasion and potential autoimmunity.”
“Summarizes identification of capsid-like proteins in venomous and parasitic animals as reported by Borges et al.”
“Evidence synthesizing that molecular mimicry by viruses enables immune evasion and triggers autoimmunity, from Maguire et al. (2024).”
“Reference describing language model-based prediction of atomic-level protein structures at evolutionary scale.”
“Reference describing the solution structure of EBV BHRF1 protein, which is homologous to human Bcl-2.”
“Reference detailing that EBV encodes a Bcl-2 homolog that inhibits apoptosis by associating with Bax and Bak.”
“Reference showing that structural homology screens identify poxvirus protein families derived from host that modulate inflammasome activity.”
“Reference describing vaccinia virus complement control protein's role in preventing complement-enhanced neutralization and contributing to virulence.”
“Reference describing vaccinia, cowpox and camelpox viruses encoding soluble gamma interferon receptors with broad species specificity.”
“Reference reporting overexpression of vaccinia virus A38L integral membrane protein promotes Ca2+ influx into infected cells.”
“Reference identifying the vaccinia virus A38L gene product as a 33-kDa integral membrane glycoprotein.”
“Reference describing the crystal structure of Epstein-Barr virus protein BCRF1, homologous to cellular interleukin-10.”
“Reference discussing proteins with the same structure but different functions.”
“Reference reporting that human poxvirus-encoded proteins bind IL-18 and inhibit interferon gamma induction.”
“Reference describing a novel inhibitor of apoptosis encoded by vaccinia virus and conserved in eukaryotes.”
“Reference reporting that a human poxvirus chemokine homolog exhibits broad spectrum chemokine antagonistic activity.”
“Reference exploring viral protein structural mimicry guided by host interactions and implications for human disease.”
“Reference describing how EBV BGLF4 kinase suppresses IRF3 signaling pathway, interfering with interferon response.”
“Evidence line providing support for using the cited reference about Chlamydomonas flagellum as a model for human ciliary disease.”
“Evidence line supporting restoration of motility in Chlamydomonas mutants modeling spermatogenic failure as described in the cited reference.”
“Evidence line describing phenotypes of a Chlamydomonas insertional mutant disrupting flagellar central pair microtubule-associated structures, supported by the cited reference.”
“Evidence line showing that actin cytoskeleton functions are conserved in absence of canonical actin-binding proteins, supported by the cited reference.”
“Evidence supporting functional distinctions and conserved roles of actin gene family members and isoforms, as referenced by (2010) The actin gene family: Function follows isoform.”