InferenceChain·arcadia

Viral Bcl-2 homologs inhibit host apoptosis

Reasoning chain explaining how viral Bcl-2 homolog proteins inhibit apoptosis by mimicking host Bcl-2 protein domains and interacting with pro-apoptotic factors.

Confidence
90%
◑partialactivecomplexity: mid

Reasoning Steps (3)

BH1 and BH2 domains important for apoptosis inhibitionStep 1
EBV BHRF1 inhibits apoptosis structurallyStep 2
EBV BALF1 antagonizes Bcl-2 family antiviral evasionStep 3

Source

Synthesis for current paper

Connections (1)

Viruses use mimicry to modulate host immunityAssociation