Association·arcadia
Large dsDNA viruses are known to use protein mimicry
Claim that large double-stranded DNA viruses like herpesviruses and poxviruses are especially known for protein mimicry strategies.
Confidence
80%
active
Evidence Quote
“Large dsDNA viruses are well known to use mimicry.”
Relationship
large dsDNA viruses uses mimicry structural mimicry
Arguments
Connections (4)
Reasoning connecting viral mimicry, immune modulation, and detection pipeline utilityInferenceChain
Petabase-scale sequence alignment increases viral discoveryAssociation
Viruses use mimicry to modulate host immunityAssociation
Evidence and reasoning on viral mimicry modulating immunity and detectionInferenceChain
Evidence
“Reference reporting host-related immunomodulators encoded by poxviruses and herpesviruses.”
(2000). Host-related immunomodulators encoded by poxviruses and herpesviruses doi:10.1016/s1369-5274(00)00107-7 ↗
“Reference detailing how EBV Bcl-2 homolog BHRF1 blocks apoptosis.”
Desbien AL et al. (2009). The Epstein–Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim doi:10.1073/pnas.0901036106 ↗
“Reference describing the function of vaccinia virus K3L protein in translation control.”
Davies MV et al. (1992). The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2 doi:10.1128/jvi.66.4.1943-1950.1992 ↗
“Evidence summarizing genome sequencing of Microplitis demolitor harboring an endogenous virus mutualist.”
Burke et al. 2018 on Microplitis demolitor genome