Association·arcadia
PGM3 is essential for immune development
Claim that PGM3 function is required for proper glycosylation, which is essential for immune development and T cell function; loss causes immunodeficiency.
Confidence
100%
active
Evidence Quote
“PGM3 function is essential for glycosylation and immune development; deficiency causes immunodeficiency and T cell defects”
Relationship
PGM3 protein enables Immune development and T cell function
Connections (2)
Evidence
“Recent review/study of PGM3 insufficiency as a glycosylation disorder affecting T cells.”
Yang L et al. (2024). PGM3 insufficiency: a glycosylation disorder causing a notable T cell defect doi:10.3389/fimmu.2024.1500381 ↗
“Case report of PGM3 deficiency treated with hematopoietic stem cell transplantation.”
Winslow A et al. (2022). A De Novo Cause of PGM3 Deficiency Treated with Hematopoietic Stem Cell Transplantation doi:10.1007/s10875-021-01196-z ↗
“Study on Agm1/Pgm3 sugar nucleotide synthesis and its role in hematopoiesis and development.”
Greig KT et al. (2007). Agm1/Pgm3-Mediated Sugar Nucleotide Synthesis Is Essential for Hematopoiesis and Development doi:10.1128/mcb.00802-07 ↗
“Study demonstrating how PGM3 mutations lead to glycosylation disorder, immunodeficiency, and skeletal dysplasia.”
Stray-Pedersen A et al. (2014). PGM3 Mutations Cause a Congenital Disorder of Glycosylation with Severe Immunodeficiency and Skeletal Dysplasia doi:10.1016/j.ajhg.2014.05.007 ↗
“Reference to Ricciardiello et al. (2018) on PGM3 inhibition causing cancer growth arrest and apoptosis.”
Ricciardiello F et al. (2018). Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis doi:10.1038/s41419-018-0405-4 ↗