Association·arcadia

PGM3 inhibition induces cancer cell apoptosis

Claim that targeting PGM3 in the hexosamine biosynthetic pathway leads to breast cancer growth arrest and apoptosis.

Confidence
80%
active

Evidence Quote

“Targeting PGM3 causes breast cancer growth arrest and apoptosis.”

Relationship

PGM3 protein decreases Breast cancer cell survival

Arguments

PGM3 proteinsubject
Breast cancer cell survivalobject

Connections (2)

Vesicle trafficking and glycosylation are central to notochord structure and immunity, with clinical and oncological implicationsInferenceChain
Animal models are poor predictors of human toxicitiesAssociation

Evidence

“Study showing that targeting PGM3 in the hexosamine biosynthetic pathway induces breast cancer growth arrest and apoptosis.”

Ricciardiello F et al. (2018). Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis doi:10.1038/s41419-018-0405-4 ↗