Detection of DNA/RNA modifications and elusive phage genomes requires specialized enrichment and sequencing methods

Reasoning that advances in DNA/RNA modification enrichment (REMoDE, mEnrich-seq) and alternative sequencing approaches (such as RNA-seq for non-sequencable DNA phages) enable the detection and study of phages with unusual or modified genomes that standard sequencing may miss, supporting claims about phage DNA novelty and detection difficulty.

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