Association·arcadia
AlphaFold database is phylogenetically biased
Claim that AlphaFold database (AFDB) shows bias in protein structure representation across species, especially overrepresenting prokaryotes.
Confidence
100%
active
Evidence Quote
“the AFDB was weighted toward prokaryotes... both databases were associated with strongly left-shifted cumulative distributions, indicating a significant proportion of their proteins come from a very small number of species.”
Relationship
AlphaFold database (AFDB) has property Phylogenetic bias
Evidence
“Evidence describing AlphaFold as an approach for highly accurate protein structure prediction, as reported by Jumper et al. (2021).”
Jumper J et al. (2021). Highly accurate protein structure prediction with AlphaFold doi:10.1038/s41586-021-03819-2 ↗