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Spaceflight triggers distinct transcriptome changes in seedlings and cell cultures

This reasoning chain explains how spaceflight exposure causes cell type-specific upregulation of distinct stress and regulatory genes, as revealed by the analysis of genes with significant p<0.01 and >5-fold expression changes. While some pathways (e.g., stress, heat shock, pathogen response) are induced in both seedlings and cultured cells, the specific gene sets differ greatly, and only MT3 is regulated in both but in opposite directions.

Confidence
80%
◑partialactivecomplexity: mid

Reasoning Steps (2)

Distinct gene sets upregulated in each cell typeStep 1
MT3 is oppositely regulated in seedlings vs. cellsStep 2

Source

Synthesis for current paper

Connections (8)

LTP6 upregulated by spaceflightAssociation
WRKY71 upregulated by spaceflightAssociation
HEMC upregulated by spaceflightAssociation
ATHSFA2 upregulated by spaceflight (cells)Association
HSP70 upregulated by spaceflight (cells)Association
WRKY8 upregulated by spaceflight (cells)Association
ATNAP8 upregulated by spaceflight (cells)Association
AGL105 upregulated by spaceflight (cells)Association