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ROS-associated gene clusters dominate suborbital DEG profile

Claim that a large portion of the differentially expressed genes in suborbital flight are ROS related, primarily from core DEGs of ROS Wheel Cluster III, which are indicative of rapid stress response.

Confidence
90%
active

Evidence Quote

“A large portion of the differentially expressed genes in suborbital flight are ROS related (Fig. 4), primarily those represented in core DEGs of ROS Wheel Cluster III.”

Relationship

t-SNE clusters of differentially expressed genes (DEGs) enriched in Reactive oxygen species (ROS) related genes

Arguments

t-SNE clusters of differentially expressed genes (DEGs)subject
Reactive oxygen species (ROS) related genesobject

Connections (5)

Inference chain for environment- and phase-specific plant transcriptomic responses in spaceInferenceChain
Spaceflight alters plant gene expressionAssociation
Mechanisms of rapid plant stress adaptation in spaceflightInferenceChain
Transcriptome adaptation in spaceflight: Root hair, oxidative, and peroxidase gene signaturesInferenceChain
Heat shock proteins, chaperones, and ROS response mediate plant adaptation in spaceflightInferenceChain

Evidence

“Citation to BMC Plant Biology 2013 paper on organ-specific Arabidopsis transcriptome remodeling in response to spaceflight.”

Paul, A.-L. et al. (2013). Organ-specific remodeling of the Arabidopsis transcriptome in response to spaceflight link ↗

“Citation to Npj Microgravity 2023 meta-analysis of Arabidopsis plant transcriptome response to space flight and microgravity.”

Barker, R. & et al. (2023). Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome link ↗

“Citation to Plant Physiology 2016 paper on refining ROS transcriptional footprints.”

Willems, P. & et al. (2016). The ROS wheel: refining ROS transcriptional footprints link ↗

“Citation to Am. J. Bot. 2015 on Arabidopsis spaceflight transcriptome and peroxidase/cell wall/root hair genes”

(2015). Transcriptional response of Arabidopsis seedlings during spaceflight reveals peroxidase and cell wall remodeling genes associated with root hair development

“Citation to Am. J. Bot. 2019 paper on ecotypic transcriptomic variation and oxidative stress signatures in Arabidopsis spaceflight responses”

(2019). Variation in the transcriptome of different ecotypes of Arabidopsis thaliana reveals signatures of oxidative stress in plant responses to spaceflight

“Citation to Front. Plant Sci. 2020 on environment for exploring Arabidopsis spaceflight transcriptome datasets”

(2020). Test of Arabidopsis space transcriptome: a discovery environment to explore multiple plant biology spaceflight experiments

“Citation to Int. J. Mol. Sci. 2019 on HSFA2 gene function in adaptation of plant cells to spaceflight”

(2019). HSFA2 functions in the physiological adaptation of undifferentiated plant cells to spaceflight

“Citation to Singh et al. 2022 Int. J. Mol. Sci. update on reactive oxygen species strategies to stave off environmental stresses in plants under climate change.”

How to cope with the challenges of environmental stresses in the era of global climate change: an update on ROS stave off in plants

“Citation to Sugimoto et al. 2014 BMC Plant Biol. on genome-wide expression analysis of the reactive oxygen species gene network in Mizuna plants grown in long-term spaceflight.”

Genome-wide expression analysis of reactive oxygen species gene network in Mizuna plants grown in long-term spaceflight

“Genome-wide expression analysis of ROS gene network in Mizuna plants after long-term spaceflight, Sugimoto et al. (2014)”

Sugimoto M et al. (2014). Genome-wide expression analysis of reactive oxygen species gene network in Mizuna plants grown in long-term spaceflight

“Correll et al. (2013) explore how Arabidopsis seedling transcriptomes respond to gravity and spaceflight.”

Correll MJ et al. (2013). Transcriptome analyses of Arabidopsis thaliana seedlings grown in space: implications for gravity-responsive genes doi:10.1007/s00425-013-1909-x ↗