Microgravity upregulates specific miRNAs

Association·nasa

Three miRNAs (miR319c, miR863-5p, miR398b-3p) are upregulated in microgravity; several of their target genes are coordinately downregulated, including stress and chloroplast-related targets.

Confidence

80%

active

Evidence Quote

“Three miRNAs (miR319c, miR398b, and miR863-5p) were upregulated in microgravity, while several of their target genes were found to be downregulated.”

Relationship

microgravity increases Spaceflight upregulated miRNAs

Arguments

Spaceflight upregulated miRNAsobject

Connections (7)

Microgravity alters plant transcriptional networks via coordinated gene set regulationInferenceChain

Spaceflight alters plant gene expressionAssociation

Microgravity triggers coordinated transcriptional shifts impacting auxin signaling, vesicle transport, and stress response in leavesInferenceChain

Gene set analysis and annotation tools enable transcriptional network interpretation in spaceflight plant studiesInferenceChain

Microgravity and space environment coordinate organelle stress and gene expression shiftsInferenceChain

Organ- and layer-specific regulation of gene expression under spaceflightInferenceChain

Crosstalk and regulatory networks coordinate plant stress responses in microgravityInferenceChain

Evidence

“miR319 and TCP transcription factors regulate spatial gene expression during leaf development.”

(2018). Spatial control of gene expression by miR319-regulated TCP transcription factors in leaf development doi:10.1104/pp.17.00823 ↗

“Spaceflight experiment identifying specific changes in Arabidopsis protein profiles.”

(2014). Spaceﬂight induces speciﬁc alterations in the proteomes of arabidopsis doi:10.1089/ast.2014.1210 ↗

“Reference describing 14-3-3 proteins in Arabidopsis brassinosteroid signaling”

Gampala SS et al. (2007). An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis

“Reference on shade-regulated localization of PIF7 mediated by 14-3-3 proteins in Arabidopsis”

Huang X et al. (2018). Shade-induced nuclear localization of PIF7 is regulated by phosphorylation and 14-3-3 proteins in Arabidopsis

“Reference on the requirement of Ser-534 for 14-3-3 binding to Arabidopsis nitrate reductase”

Kanamaru K et al. (1999). Ser-534 in the Hinge 1 region of Arabidopsis nitrate reductase is conditionally required for binding of 14-3-3 proteins and in vitro inhibition

“The AP2/EREBP family of plant transcription factors.”

(1998). The AP2/EREBP family of plant transcription factors

“Reference on organ-specific microRNAs and their functional roles in Arabidopsis.”

Expression-based functional investigation of the organ-specific microRNAs in Arabidopsis