Association·nasa
Gene family enrichment is phase- and organ-dependent in suborbital flight
Claim that enrichment of specific gene families among differentially expressed genes is dependent on both phase (flight timepoint) and organ (root/leaf) during suborbital spaceflight.
Confidence
90%
active
Evidence Quote
“Clusters were marked by phase and/or organ-dependent up- or down-regulation of DEGs. Enrichment analysis identified representative gene families that were altered in roots and leaves in different phases of suborbital spaceflight.”
Relationship
t-SNE clusters of differentially expressed genes (DEGs) enriched by phase and organ Cluster-enriched gene families in suborbital spaceflight
Arguments
Connections (8)
Cluster-enriched gene families in suborbital spaceflightFactor
Inference chain for environment- and phase-specific plant transcriptomic responses in spaceInferenceChain
Spaceflight alters plant gene expressionAssociation
Experimental pipeline and hardware enable rapid transcriptomic profilingInferenceChain
Organ- and context-dependent plant transcriptome responses to spaceflightInferenceChain
Transcriptome adaptation in spaceflight: Root hair, oxidative, and peroxidase gene signaturesInferenceChain
Bioinformatic workflows underpin phase- and organ-enriched transcriptomic discoveryInferenceChain
Supplementary material strengthens experimental conclusionsInferenceChain
Evidence
“Citation to Npj Microgravity 2023 meta-analysis of Arabidopsis plant transcriptome response to space flight and microgravity.”
Barker, R. & et al. (2023). Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome link ↗
“Citation to BMC Plant Biology 2013 paper on organ-specific Arabidopsis transcriptome remodeling in response to spaceflight.”
Paul, A.-L. et al. (2013). Organ-specific remodeling of the Arabidopsis transcriptome in response to spaceflight link ↗
“Citation to Correll et al. 2013 Planta paper on transcriptome analyses of Arabidopsis seedlings grown in space, with implications for gravity-responsive genes.”
Transcriptome analyses of Arabidopsis thaliana seedlings grown in space: implications for gravity-responsive genes