Association·arcadia
Torin2 rescues motility in ida4 cells
Torin2 treatment significantly recovers motility defects in ida4 mutant Chlamydomonas cells
Confidence
100%
active
Evidence Quote
“Torin2 did significantly recover motility in ida4 cells”
Relationship
Torin2 increases Chlamydomonas reinhardtii motility
Connections (7)
Drug-specific effects on mutant motility phenotypesInferenceChain
Vesicle trafficking and glycosylation are required for notochord lumen inflationAssociation
Mechanistic reasoning on flagellar mutant phenotypes and motilityInferenceChain
Mechanistic reasoning on drug effects modulating Chlamydomonas motilityInferenceChain
Reasoning on drug-specific effects on mutant motility phenotypesInferenceChain
Torin2 mechanism explaining motility recoveryInferenceChain
Reasoning on flagellate motility assessment methods and effectsInferenceChain
Evidence
“Inline reference describing Torin2 as an ATP-competitive inhibitor of mTOR, ATM, and ATR”
Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR doi:10.1158/0008-5472.can-12-1702 ↗
“Inline reference describing targeting mTOR complex activity with Torin2 in thyroid carcinoma”
Ahmed M et al. (2014). High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma doi:10.1093/carcin/bgu051 ↗
“Inline reference describing torins as potent antimalarials targeting parasite membrane proteins”
Hanson KK et al. (2013). Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins doi:10.1073/pnas.1306097110 ↗
“Inline reference discussing TOR inhibitors in mammals and their pharmacogenetics in plants and algae”
Montané M-H & Menand B (2019). TOR inhibitors: from mammalian outcomes to pharmacogenetics in plants and algae doi:10.1093/jxb/erz053 ↗