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Mechanistic reasoning on flagellar mutant phenotypes and motility

Logical reasoning connecting specific flagellar mutants, their molecular defects, and observed motility phenotypes to understand causative mechanisms underlying motility changes in Chlamydomonas and sperm flagella.

Confidence
85%
◑partialactivecomplexity: mid

Reasoning Steps (3)

Role of flagellar central pair proteins in motilityStep 1
Function of inner-arm dynein in microtubule sliding and motilityStep 2
Correlation of genotype with motility phenotype in flagellar mutantsStep 3

Source

Synthesis for current paper

Connections (5)

Torin2 rescues motility in ida4 cellsAssociation
Linsitinib worsens ida4 motilityAssociation
Ibudilast worsens ida4 motilityAssociation
Dynarrestin does not worsen ida4 motilityAssociation
TAK-063 recovers cpc1-1 motilityAssociation