Proteins within clusters function similarly — ARCADIA Knowledge Graph

Association·arcadia

Proteins within clusters function similarly

Hypothesis and claim that proteins clustered together by ProteinCartography function similarly; to be tested by characterizing uncharacterized proteins in LC00 compared to HRas and their GTPase activity.

Confidence
80%
active

Evidence Quote

“We’ll be testing the hypotheses that proteins clustered together function similarly; characterize uncharacterized proteins from LC00 compared to HRas.”

Relationship

LC00 correlates HRas

Arguments

Leiden protein clustersubject
Leiden protein clusterobject

Connections (2)

Reasoning on structural clustering and protein function in Ras GTPasesInferenceChain
Structural similarity often diverges from sequence similarityAssociation

Evidence

“Reference on ProteinCartography for interactive structure-based protein comparison.”

(2024). ProteinCartography: Comparing proteins with structure-based maps for interactive exploration doi:10.57844/ARCADIA-A5A6-1068 ↗

“Reference on using evolutionary approaches to identify new organismal models for human biology.”

(2024). Leveraging evolution to identify novel organismal models of human biology doi:10.57844/ARCADIA-33B4-4DC5 ↗