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Association·arcadia

Proteins in different clusters have different functions

Hypothesis and claim that proteins in different clusters (e.g. LC03, LC06, LC09) have different functions, to be tested by comparison with proteins in LC00.

Confidence
80%
active

Evidence Quote

“We’ll be testing the hypothesis that proteins in different clusters have different functions; compare proteins from LC03, LC06, LC09 with those in LC00.”

Arguments

Leiden protein clustersubject
LC03 cluster (fungal homologs)object

Connections (4)

LC06 cluster (mixed taxa, GTPase annotation)Factor
LC09 cluster (arthropod-rich, GTP-binding annotation)Factor
Reasoning on structural clustering and protein function in Ras GTPasesInferenceChain
Structural similarity often diverges from sequence similarityAssociation

Evidence

“Reference on ProteinCartography for interactive structure-based protein comparison.”

(2024). ProteinCartography: Comparing proteins with structure-based maps for interactive exploration doi:10.57844/ARCADIA-A5A6-1068 ↗

“Reference on using evolutionary approaches to identify new organismal models for human biology.”

(2024). Leveraging evolution to identify novel organismal models of human biology doi:10.57844/ARCADIA-33B4-4DC5 ↗