Association·arcadia
Polymerization is an important criterion for true actin
Claim that the ability to polymerize is a highly important characteristic in deeming a protein a true actin, as found in all actins and many actin-like proteins but not in actin-related proteins.
Confidence
80%
active
Evidence Quote
“A candidate protein’s ability to polymerize is a highly important characteristic in deeming it a “true” actin.”
Relationship
Polymerization ability important for actin
Arguments
Connections (4)
Reasoning: Functional criteria for true actin identificationInferenceChain
Structural similarity often diverges from sequence similarityAssociation
Reasoning: Evolutionary divergence and functional conservation of actinInferenceChain
Reasoning: Evolutionary conservation and divergence of actin structure and functionInferenceChain
Evidence
“Reference about actin polymerization mechanism from cryo-EM studies”
Chou SZ & Pollard TD (2019). Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides doi:10.1073/pnas.1807028115 ↗
“Reference on structures and mechanisms of actin ATP hydrolysis”
Kanematsu Y et al. (2022). Structures and mechanisms of actin ATP hydrolysis doi:10.1073/pnas.2122641119 ↗