Association·arcadia

Phylogenetic bias in databases influences protein model outcomes

Claim that the phylogenetic bias in protein structure databases affects the statistical utility and outcomes of protein prediction and design models.

Confidence
90%
active

Evidence Quote

“phylogenetic bias ... influences the statistical utility of the known protein universe in important ways”

Relationship

Phylogenetic bias influences Protein prediction and design models

Arguments

Phylogenetic biassubject
Protein prediction and design modelsobject

Connections (3)

Reasoning chain: Phylogenetic bias affects protein design modelsInferenceChain
Structural similarity often diverges from sequence similarityAssociation
Tree-of-life sampling and algorithmic biases shape the performance of protein language/design modelsInferenceChain

Evidence

“Evidence summarizing progress and applications in deep learning for protein structure prediction and protein design as reported by Jänes and Beltrao (2024).”

Jänes J & Beltrao P. (2024). Deep learning for protein structure prediction and design—progress and applications doi:10.1038/s44320-024-00016-x ↗