Association·arcadia
Non-additive interactions like epistasis drive phenotypic variation
Claim that gene-gene interactions such as epistasis are prevalent and important sources of phenotypic variation, violating classic assumptions of additivity and independence.
Confidence
90%
active
Evidence Quote
“A clear example of such nonlinear relationships is epistasis, in which the effect of one gene can mask or modify the phenotypic impact of another.”
Relationship
gene interactions increases phenotypic var
Connections (5)
Limitations of additive models motivate information theory in geneticsInferenceChain
Non-additive interactions like epistasis drive phenotypic variationAssociation
Information theory enables tractable quantification of genetic interactionsInferenceChain
Explaining the significance of epistasis in quantitative geneticsInferenceChain
Epistasis is central to genetic system structure and evolutionInferenceChain
Evidence
“Reference to Phillips' 2008 article on epistasis and gene interactions”
Phillips, PC. (2008). Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems doi:10.1038/nrg2452 ↗
“Reference on epistasis and studies of gene–gene interactions in quantitative traits”
Mackay TFC. (2013). Epistasis and quantitative traits: using model organisms to study gene–gene interactions doi:10.1038/nrg3627 ↗
“Model organism studies of gene-gene interactions”
Mackay TFC (2013). Epistasis and quantitative traits: using model organisms to study gene–gene interactions doi:10.1038/nrg3627 ↗
“Perspective on Falconer and quantitative genetics”
Hill WG & Mackay TFC (2004). D. S. Falconer and Introduction to Quantitative Genetics doi:10.1093/genetics.167.4.1529 ↗
“Reference on genomic factors in Mendelian disorders”