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Molecular conservation measured by phylogenetically-corrected protein properties

Association stating that molecular conservation with humans is measured by calculating protein physicochemical properties, correcting for evolutionary relatedness, and using Mahalanobis distance.

Confidence
90%
active

Evidence Quote

“Molecular conservation calculated via protein physicochemical properties corrected for phylogeny”

Relationship

Molecular conservation measured by Protein physicochemical properties

Arguments

Molecular conservationsubject
Protein physicochemical propertiesobject

Connections (2)

Partitioning sources of molecular conservation variationInferenceChain
Structural similarity often diverges from sequence similarityAssociation

Evidence

“Reference to the EukProt database paper providing a resource of predicted proteins in eukaryotes.”

(2022). EukProt: A database of genome-scale predicted proteins across the diversity of eukaryotes doi:10.24072/pcjournal.173 ↗

“Reference for the OrthoFinder software for orthology inference.”

Emms DM & Kelly S (2019). OrthoFinder: phylogenetic orthology inference for comparative genomics doi:10.1186/s13059-019-1832-y ↗

“Reference for methodology improvements in orthogroup inference with OrthoFinder.”

Emms DM & Kelly S (2015). OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy doi:10.1186/s13059-015-0721-2 ↗

“Reference for the cogeqc R/Bioconductor package for assessing comparative genomics data quality.”

Almeida‐Silva F & Van de Peer Y (2023). Assessing the quality of comparative genomics data and results with the cogeqc R/Bioconductor package doi:10.1111/2041-210x.14243 ↗

“Reference describing the NovelTree workflow for fast phylogenomic inference.”

Celebi FM et al. (2024). NovelTree: Highly parallelized phylogenomic inference doi:10.57844/ARCADIA-Z08X-V798 ↗