Association·arcadia
Length outliers indicate gene fusion in venom proteins
Claim that proteins emerging as length outliers among toxin homologs likely result from gene fusion events between toxin and accessory domains.
Confidence
80%
active
Evidence Quote
“Proteins emerging as length outliers among toxin homologs potentially indicating fusion events”
Relationship
Length outlier proteins indicates Gene fusion
Connections (8)
Length outliers indicate gene fusion eventsInferenceChain
Bracovirus capsid HMM detects capsid in Microplitis demolitorAssociation
Gene fusionFactor
Accessory sequence clusters are species- and toxin-specificInferenceChain
Gene fusion events in venom proteinsInferenceChain
Venom evolution shaped by development and life-historyInferenceChain
Convergent evolution of venom gland transcriptomesInferenceChain
Methodological basis of MMseqs2 protein sequence analysisInferenceChain
Evidence
“Summarizes experimental and computational evidence supporting MMseqs2"s sensitivity and efficiency as documented in Steinegger and Söding"s publications.”
Synthesis for current paper
“Evidence summarizing the study identifying candidate accessory domains in toxin proteins via gene fusion in venomous species, highlighting lack of conservation and functional annotation challenges.”
Adair L. Borges et al.. Identifying candidate accessory domains by mining putative venom protein fusions doi:10.57844/arcadia-d3dc-7499 ↗