Association·arcadia

LC09 proteins share fold with HRas

Claim that LC09 proteins have a similar overall fold to human HRas (average TM-score 0.88) and to LC03 cluster.

Confidence
90%
active

Evidence Quote

“LC09 cluster proteins have highly similar folds to human HRas and to all fungal proteins in LC03 (average TM-score 0.88).”

Relationship

LC09 cluster (arthropod-rich, GTP-binding annotation) shares fold Human HRas protein

Arguments

LC09 cluster (arthropod-rich, GTP-binding annotation)subject
Human HRas proteinobject

Connections (3)

LC03 cluster (fungal homologs)Factor
Reasoning on structural clustering and protein function in Ras GTPasesInferenceChain
Structural similarity often diverges from sequence similarityAssociation

Evidence

“Reference on ProteinCartography for interactive structure-based protein comparison.”

(2024). ProteinCartography: Comparing proteins with structure-based maps for interactive exploration doi:10.57844/ARCADIA-A5A6-1068 ↗