Association·arcadia
Gene interactions violate additivity and independence assumptions
Claim that observed gene-gene interactions such as epistasis contradict the additive and independent model in classic quantitative genetics, which may limit analysis accuracy.
Confidence
90%
active
Evidence Quote
“Gene-gene interactions such as epistasis contradict the additive and independent model in classic quantitative genetics.”
Relationship
gene interactions contradicts add indep model
Connections (5)
Limitations of additive models motivate information theory in geneticsInferenceChain
Non-additive interactions like epistasis drive phenotypic variationAssociation
Information theory enables tractable quantification of genetic interactionsInferenceChain
Explaining the significance of epistasis in quantitative geneticsInferenceChain
Epistasis is central to genetic system structure and evolutionInferenceChain
Evidence
“Reference discussing Falconer and quantitative genetics models”
Hill WG & Mackay TFC. (2004). D. S. Falconer and Introduction to Quantitative Genetics doi:10.1093/genetics/167.4.1529 ↗
“Review of the progression from Fisher’s model to GWAS”
Visscher PM & Goddard ME (2019). From R.A. Fisher’s 1918 Paper to GWAS a Century Later doi:10.1534/genetics.118.301594 ↗
“Reference to Galton regression in hereditary stature”