Epistasis groups indicate functional gene relationships — ARCADIA Knowledge Graph

Association·arcadia

Epistasis groups indicate functional gene relationships

Claim that genes grouped as epistasis groups are functionally related since mutating any one gene produces the same phenotype, implying a shared functional unit.

Confidence
90%
active

Evidence Quote

“Genes grouped as epistasis groups are functionally related; mutating any one gene produces the same phenotype.”

Relationship

Epistasis groups implies functional gene relation

Arguments

Epistasis groupssubject

Connections (3)

Limitations of additive models motivate information theory in geneticsInferenceChain
Non-additive interactions like epistasis drive phenotypic variationAssociation
Epistasis is central to genetic system structure and evolutionInferenceChain

Evidence

“Reference to yeast cell-division cycle genetic control mutants”

(1970). Genetic Control of the Cell-Division Cycle in Yeast, I. Detection of Mutants doi:10.1073/pnas.66.2.352 ↗

“Review of progress in cell-cycle genetics”

Reid BJ et al. (2015). Forty-five years of cell-cycle genetics doi:10.1091/mbc.e14-10-1484 ↗