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Endogenized viral capsids may mediate gene delivery

Suggests that endogenized viral capsid proteins in parasitic species could participate in nucleic acid/gene delivery to host cells.

Confidence
70%
active

Evidence Quote

“Capsids from human parasites may participate in gene delivery to human cells.”

Relationship

venomous species endogenized capsids enables gene delivery to hosts

Arguments

Putative endogenized capsid in parasitoid wasps and a spidersubject

Connections (4)

Reasoning for viral capsid enrichment in parasitic speciesInferenceChain
Bracovirus capsid HMM detects capsid in Microplitis demolitorAssociation
Reasoning about viral capsid domestication and parasitic host interactionsInferenceChain
Host adaptation of retroelement-derived capsid proteins in animalsInferenceChain

Evidence

“Study describing dual functions of Bracovirus C-type lectin in caterpillar immune manipulation”

(2022). The Dual Functions of a Bracovirus C-Type Lectin in Caterpillar Immune Response Manipulation doi:10.3389/fimmu.2022.877027 ↗

“Reference to Segel M et al. (2021) describing PEG10 packaging its own mRNA and pseudotyping for delivery.”

Segel M et al. (2021). Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery doi:10.1126/science.abg6155 ↗