Circular DNA produces large insert sizes
Circularized DNA creates insert size distributions with unexpectedly large mapped distances between paired reads.
Evidence Quote
“Circular DNA creates paired reads with mapped distances far longer than expected (~300 bp), resulting in large insert sizes.”
Relationship
Connections (4)
Evidence
“nf-core circdna pipeline for extrachromosomal circular DNA detection.”
“ecc_finder: A robust and accurate tool for detecting extrachromosomal circular DNA.”
“Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data.”
“eccDNA-pipe: an integrated pipeline for identification, analysis, and visualization of extrachromosomal circular DNA.”
“Extrachromosomal circular DNA is common in yeast.”
“Endogenous circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens.”
“FLED: a full-length eccDNA detector for long-reads sequencing data.”
“ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines.”
“Reference describing Minimap2 software for nucleotide sequence alignment”
“Fast and accurate short read alignment with Burrows–Wheeler transform.”
“The Sequence Alignment/Map format and SAMtools.”
“BEDTools: a flexible suite of utilities for comparing genomic features.”
“Reference to the fastp tool for FASTQ data preprocessing”
“NCBI SRA Tools for sequence data processing.”