Association·arcadia
Actin structure is broadly conserved across distant homologs
Despite evolutionary distance or low sequence identity, overall actin structure is similar across rabbit, Giardia, Lokiarchaeota, and MreB examples.
Confidence
80%
active
Evidence Quote
“Overall actin structure is quite similar across highly divergent homologs”
Relationship
rabbit cytoplasmic actin conserved giardia actin
Connections (4)
MreB (bacterial actin-like protein, AlphaFold: AF-P0A9X4-F1)Factor
Structural similarity often diverges from sequence similarityAssociation
Reasoning: Evolutionary divergence and functional conservation of actinInferenceChain
Reasoning: Evolutionary conservation and divergence of actin structure and functionInferenceChain
Evidence
“Reference on actin structure and function”
Dominguez R & Holmes KC (2011). Actin Structure and Function doi:10.1146/annurev-biophys-042910-155359 ↗