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Association·nasa

Remodeling of central metabolic pathways is common in altered gravity

Claim that central metabolic remodeling (amino acid, carbon, and sulfur metabolism) is commonly affected by altered gravity and is a hallmark of Arabidopsis flight experiment responses.

Confidence
80%
active

Evidence Quote

“The KEGG enrichments thus outlined the involvement of metabolic remodeling processes generally associated with amino acids, carbon, and sulfur in the AGR”

Relationship

Central metabolic pathways remodels altered gravity env

Arguments

Central metabolic pathwaysobject

Connections (3)

Reasoning linking genotype, platform, and stressors to metabolic remodelingInferenceChain
Literature-backed reasoning for transcriptome and pathway interpretationInferenceChain
Functional database and literature evidence explain pathway remodeling claimsInferenceChain

Evidence

“Reference discussing origins and evolution of cellular life”

(2019). Toward understanding the origin and evolution of cellular organisms

“Reference for RSEM tool for RNA-Seq quantification”

Li B & Dewey CN (2011). RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome doi:10.1186/1471-2105-12-323 ↗

“Reference for KEGG database and pathway resource”

Kanehisa M & Goto S (2000). KEGG: Kyoto Encyclopedia of Genes and Genomes doi:10.1093/nar/28.1.27 ↗

“Reference for ThaleMine Arabidopsis data warehouse”

Krishnakumar V et al. (2016). ThaleMine: a warehouse for Arabidopsis data integration and discovery doi:10.1093/pcp/pcw220 ↗